Neural gene expression in Pten knock-in mice at 6-weeks of age

The goal of this study was to assess the changes in the neural transcriptome of Ptenm3m4 mice, in order to better understand their ASD-related phenotypes. For our initial cellular and behavioral characterization of this mouse line, see Tilot, et al., Human Molecular Genetics, 2014 Comparison of mice heterozygous and homozygous for the Ptenm3m4 mutation to Wt littermates at 2 and 6 weeks of age本研究旨在评估Ptenm3m4小鼠的神经转录组（neural transcriptome）变化，以更好地理解其孤独症谱系障碍（Autism Spectrum Disorder，ASD）相关表型。有关该小鼠品系的初始细胞与行为学特征表征，请参阅Tilot等学者2014年发表于《人类分子遗传学》（Human Molecular Genetics）的研究：《2周龄与6周龄Ptenm3m4突变杂合子、纯合子小鼠与野生型（wild type，Wt）同窝仔鼠的比较》（Comparison of mice heterozygous and homozygous for the Ptenm3m4 mutation to Wt littermates at 2 and 6 weeks of age）。