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IGF2BP3 Inhibits Translation in Round Spermatozoa

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP490309
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To reveal the effects of IGF2BP3 on mouse spermatids at the post-transcriptional and translational levels, we performed RNA-seq and ribosome nascent-chain complex sequencing (RNC-seq) of spermatids from Igf2bp3+/- and Igf2bp3-/- mice after isolation. RNA-seq and RNC-seq sequencing showed that IGF2BP3 mainly plays a regulatory role in translational repression in spermatids. Overall design: RNA-seq and RNC-seq of spermatids from Igf2bp3+/- and Igf2bp3-/- mouse testes by flow sorting. Three biological replicates per sample.
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2025-11-30
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