Distinct functional patterns in modules predicting survival in different tumor types.

Shown is a summary of properties of immune molecular modules whose expression in tumors significantly predicts patient survival. Bold font denotes modules showing significant splits at p-value <1e-3 (<1 false positive expected by chance); normal font denotes modules associated with survival at p-value <5e-3 (~1 false positive expected by chance). No. random samples, the number of random sample partitions (N = 526) exceeding the significance threshold for each tumor; No. random gene sets, number of random gene sets (N = 526) exceeding significance threshold; No. modules, total number of modules exceeding significance threshold; No. clusters, number of clusters of modules with overlapping genes (>25% overlap); selected top module, representative top module from a cluster comprising at least two modules with overlapping genes or similar annotation; top module annotation, representative annotation term associated with module (S2 Table);NA, not applicable. The modules reaching significance with Rectal tumors did not share gene overlap or annotation and were therefore considered “NA”.
Distinct functional patterns in modules predicting survival in different tumor types.