A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory diseases

Experimental autoimmune uveoretinitis, a mouse model of ocular autoimmunity, was induced by immunization with the uveitogenic peptide IRBP1-20. 26 days after disease induction, CD4 T cells were purified by cell sorting for RNAseq. Overall design: Data from 12 samples obtained from C57BL/6 mice immunised with the uveitogenic peptide IRBP 1-20 and adjuvants. CD4+ T cells were obtained 26 days after disease by sorting from individual eyes (8 samples) or from the spleens of animals with disease (2 mice, A2S&B3S) or naïve (2 mice, A3S&B1S).