Gene expression signature of liver of mice with and without functional NNT

Global RNA sequencing analysis of liver of chow and high-fat diet fed WT and NNT KO mice (both sexes) Overall design: At the age of 11-13 weeks, half of the mouse cohort (female as well as male mice) were switched from chow to a 45 kcal% Fat (ssniff E15744-347, according to research diets D12451). After 11 weeks of HFD feeding, mice were sacrificed 2–4,5 h after the lights went on, and serum and tissue samples were collected.