Data_Sheet_1_Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds.PDF
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https://figshare.com/articles/dataset/Data_Sheet_1_Exploitation_of_the_Ugi_5-Center-4-Component_Reaction_U-5C-4CR_for_the_Generation_of_Diverse_Libraries_of_Polycyclic_Spiro_Compounds_PDF/7228709
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An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying two orthogonally protected secondary amines. Libraries of compounds were obtained decorating the molecules through acylation/reductive amination reactions on these functional groups.
创建时间：
2018-10-19
