Evaluation of CD133 and CD24 cancer stem cells and their different phenotypes in bladder carcinoma.

The heterogeneous molecular pathogenesis of bladder cancer and the frequent recurrence of superficial urothelial carcinoma suggest the contribution of cancer stem cells (CSCs) in their tumourgenicity. Although Identification of CSCs is ultimately needed for the success of targeted therapies, their origin and induction process are still ambiguous. Experimental evidence indicates that CSCs are not exactly akin, whereas, various subpopulations reside within a cancer mass and possess different capacity of tumorigenesis. This study investigated the relationship and clinical significance of two putative CSC markers, CD133 and CD24, and, their different phenotypes in patients with urinary bladder carcinoma.

膀胱癌的异质分子发病机制及其表浅尿路上皮癌的频繁复发，暗示癌干细胞（CSCs）在其肿瘤发生学中发挥着重要作用。尽管识别CSCs对于靶向疗法的成功至关重要，但它们的起源及诱导过程仍然模糊不清。实验证据表明，CSCs并非完全相同，而是存在多种亚群，这些亚群分布于肿瘤体内，并具有不同的肿瘤发生能力。本研究探讨了两种假定的CSC标记物，CD133和CD24，及其在膀胱癌患者中的不同表型之间的关系及其临床意义。