Alpha modulation of spiking activity across multiple brain regions in mice performing a tactile selective detection task

Many cognitive and sensory processes are characterized by strong relationships between the timing of neuronal spiking and the phase of ongoing local field potential oscillations. The coupling of neuronal spiking in the neocortex to the phase of alpha oscillations (8-12 Hz) has been well studied in nonhuman primates but remains largely unexplored in other mammals. How this alpha modulation of spiking differs between brain areas and cell types, as well as its role in sensory processing and decision making, is not well understood. We used Neuropixels 1.0 probes to chronically record neural activity from the somatosensory cortex, prefrontal cortex, striatum, and amygdala in mice performing a whisker-based selective detection task. We observed strong spontaneous alpha modulation of single-neuron spiking activity during inter-trial intervals while mice performed the task. The prevalence and strength of alpha phase modulation differed significantly across regions and between cell types. Phase ..., , # Alpha modulation of spiking activity across multiple brain regions in mice performing a tactile selective detection task

Dataset DOI: [10.5061/dryad.905qftv02](https://doi.org/10.5061/dryad.905qftv02)

## Description of the data and file structure

The data provided here comes from Neuropixels 1.0 recordings in 4 mice (2 in the prefrontal cortex, 2 in the somatosensory cortex) as they performed a tactile selective detection task. We used this data to explore alpha band modulation of single-unit spiking data in the context of the behavior. This data has been processed from its raw format into MATLAB tables. The compressed raw data is over 2.1 TB in size. Requests for the raw data can be made to Prof. Qi Wang ([[e-mail]]([e-mail])).

To place the data in a folder structure compatible with the software listed below, create a base-level folder (referred to here as **Base**). Unzip Subjects.zip to the **Base** folder, and create a sub-folder named **Data**. In **Data...,