S14 Table -

Tetramer matching to novel N-termini in proteins secreted by HEK293 cells following treatment with MMP-2 (A) and MMP-9 (B). Each table contains sequences of deduced cleavages grouped according to two thresholds: a) IE > 1σ above the mean value of isotopic enrichment of the corresponding N-terminally labeled peptides, and b) RP values of the matching tetramers above MMP specific cutoff defining the selectome. For each identified cleavage the following information has been provided: the rank and RP of the matching tetramer, isotopic enrichment (log2(ratio)) and p-value for each N-terminally labeled peptide based on duplicate determinations and respective protein ids. The tabs: C, D, E, F, G contain the same information as above, but for novel N-termini in proteins grouped according to their matching tetramers belonging to various parts of Venn’s diagram in Fig 5. In each tab the isotopic enrichment, IE, RP and p values have been specified as they were determined for both MMP-2 and 9 enzymes. (C)–MMP-2 cleaved proteins belonging to common set of MMP-2-9 selectomes (45 entries), (D)–MMP-9 cleaved proteins belonging to common set of MMP-2-9 selectomes (50 entries), (E)–MMP-2 cleaved proteins belonging to unique part of MMP-2 selectome (15 entries), (F)–MMP-9 cleaved proteins belonging to unique part of MMP-9 selectome (10 entries). (XLSX)