Synergistic Exacerbation of Oral Streptococci-induced pneumonia due to Prevotella intermedia

Anaerobic bacteria in the oral cavity can cause respiratory infections. However, their precise mechanisms of action remain elusive. Unexpectedly, bacterial flora analysis using 16s rRNA revealed 'hidden' mixed infections of anaerobic bacteria and commensal oral Streptococcus species in community-acquired pneumonia. The purpose of this study is to elucidate the mechanisms by which Prevotella intermedia exacerbates oral streptococcal pneumonia. Overall design: Total RNA of lungs extracted from 12 hours post infection with Streptococcus anginosus and the supernatants of Prevotella intermedia (OMA.14) or control medium (GAM) were compared.