Bioavailability and exposure fraction (AUCinf) of I2S in the serum and CSF after IT-L dosing.
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AUCinf, area under the concentration-time curve extrapolated to infinity; CM, cisterna magna; CSF, cerebrospinal fluid; EF, exposure fraction; F, bioavailability; I2S, iduronate-2-sulfatase; IT-L, intrathecal lumbar; IV, intravenous.aMean body weights were calculated from the animals whose CSF samples were collected at the CM level.bSampled at CM level.Bioavailability and exposure fraction (AUCinf) of I2S in the serum and CSF after IT-L dosing.
创建时间：
2015-12-03
