Transcription profiling of fetal livers of UPF2 null mice

Deletion of the NMD component UPF2 in fetal liver. Upf2flox/+ females were mated to Upf2flox/+; Alfp-Cre males. Fetal livers were isolated from Upf2+/+; Alfp-Cre (WT) and Upf2flox/flox; AlfpCre (UPF2 null) E16.5 and E18.5 embryos.胎肝中无义介导的mRNA降解（Nonsense-mediated mRNA Decay，NMD）通路组分UPF2的敲除。将Upf2flox/+雌性小鼠与Upf2flox/+; Alfp-Cre雄性小鼠进行交配。从胚胎发育第16.5天（E16.5）和第18.5天（E18.5）的Upf2+/+; Alfp-Cre（野生型，Wild Type）以及Upf2flox/flox; AlfpCre（UPF2敲除型，UPF2 null）胚胎中分离胎肝。