Crystal structure of Cytochalasin D bound to a filamentous conformation actin

Crystal structure of Cytochalasin D bound to a filamentous conformation actin Descriptor: (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Takeda, S, Maeda, Y, Fujiwara, I. Deposit date: 2024-12-17 Release date: 2025-07-02 Last modified: 2025-07-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Microscopic and structural observations of actin filament capping and severing by cytochalasin D. Proc.Natl.Acad.Sci.USA, 122, 2025