Tsimane physiological dysregulation data

Humans have the longest post-reproductive lifespans and lowest rates of actuarial aging among primates. Understanding the links between slow actuarial aging and physiological change is critical for improving the human “healthspan”. Physiological dysregulation may be a key feature of aging in industrialized populations with high burdens of chronic “diseases of civilization”, but little is known about age trajectories of physiological condition in subsistence populations with limited access to public health infrastructure. To better characterize human physiological dysregulation, we examined age trajectories of 40 biomarkers spanning the immune (n=13 biomarkers), cardiometabolic (n=14), musculoskeletal (n=6), and other (n=7) systems among Tsimane forager-horticulturalists of the Bolivian Amazon using mixed cross-sectional and longitudinal data (n=22,115 observations). We characterized age-related changes using a multi-system statistical index of physiological dysregulation (Mahalanobis di...