Effect of Rosmarinic acid in Pseudomonas aeruginosa PAO1 at expression level

We report a next-generation sequencing of total RNA from Pseudomonas aeruginosa PAO1 grown in presence of rosmarinic acid (RA) 100mM. Data analysis in comparison with cells grown in absence of RA revealed that the plant compound RA induces a broad transcriptional response in this bacterium, quite similar to the quorum sensing response. RNAseq of three samples of Pseudomonas aeruginosa PAO grown with rosmarinic acid 100 uM and three samples of the same bacterium grown without rosmarinic acid (control). As rosmarinic acid was dissolved in DMSO, the same amount of DMSO was added to the control cultures.