The role of ALKBH5 in maternal RNA decay during mammalian oocyte meiosis [RNA-seq]

To investigate the function of ALKBH5 in the regulation of maternal RNA decay during mice oocyte meiosis, we established Alkbh5 knockout mice and analyzed the transcriptome changes between control and Alkbh5 knockout oocyte at different meiotic maturation stages Comparative gene expression profiling analysis of RNA-seq data for control and Alkbh5 knockout oocytes at different stages为探究ALKBH5在小鼠卵母细胞减数分裂过程中调控母源RNA降解的功能，本研究构建了Alkbh5基因敲除小鼠，对不同减数分裂成熟阶段的对照组与Alkbh5基因敲除卵母细胞间的转录组变化进行了分析，并针对不同发育阶段的对照组及Alkbh5基因敲除卵母细胞的RNA测序（RNA-seq）数据开展了对比基因表达谱分析。