M protein gets N-glycosylated

This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.<br><br>Protein M is exclusively N-glycosylated at one asparagine by an unknown glycosyltransferase. However, further processing of N-linked glycans is prevented in infected cells. Both the glycosylated and nonglycosylated M is incorporated into the virion. In summary, glycosylation of M is neither a prerequisite for intra-cellular transport nor for recruitment into the virion (Voss et al, 2006).

此次COVID-19事件系由SARS-CoV-1数据经计算推理（参见https://reactome.org/documentation/inferred-events）与人工编纂相结合而形成，具体编纂过程详述于SARS-CoV-2感染途径的概述中。蛋白质M在单一天冬酰胺上由一种未知的糖基转移酶进行N-糖基化。然而，在感染细胞中，N-连接糖基的进一步加工受到阻碍。无论是糖基化还是非糖基化的M蛋白，均被纳入病毒颗粒中。综上所述，M蛋白的糖基化既非细胞内运输的先决条件，亦非病毒颗粒招募的必要条件（Voss等，2006年）。