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Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI.

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP292630
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We show that an effective GvL is associated with a substantial drop of CD8+ TRB diversity and a concomitant expansion of dominant clones. Overall design: TRB sequencing of sorted CD8+ T cells comparing leukemia patients with and without GvL effect after therapeutic DLI; SupplementalTables.docx containing sTable 1 "Patient samples" and sTable2 "Response to DLI"
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2021-11-17
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