While oncogenes can potentially be inhibited with small molecules, the loss of tumor suppressors is more common and presents a conundrum for precision therapy because the proteins are no longer presen
Transcriptional responses to external stimuli remain poorly understood. Using GRO-Seq and PRO-Seq, we show that CDK8 kinase activity promotes RNA polymerase II (RNAPII) pause release in response to IF
Ubiquitin-specific protease 18 (USP18, also known as UBP43) has both interferon stimulated gene 15 (ISG15) dependent and ISG15-independent functions. By silencing the expression of USP18 in HepG2.2.15
Triplet repeat siRNAs as found amplified in diseases such as Huntingtons disease can be used to kill cancer cells RNA isolated from HeyA8 cells 48 hrs after transfection with either a nontargeting siR
