NTF3 binds NTRK3

Neurtrophin-3 (NTF3, also known as NT-3) is the main ligand for the neuronal receptor tyrosine kinase NTRK3 (TRKC) (Lamballe et al. 1991). NTRK3 is not activated by other member of the neurotrophin family (NGF, BDNF and NTF4) (Lamballe et al. 1991, Ip et al. 1993). Binding to the NTF3 homodimer induces dimerization of the NTRK3 (TRKC) receptor, so that the stoichiometry of the ligand:receptor complex is 2:2 (Philo et al. 1994). In the study by Philo et al., a recombinant human NTF3 was used with a recombinant extracellular region of NTRK3, but the origin of NTRK3 was not specified.

神经生长因子-3（NTF3，亦称NT-3）是神经元受体酪氨酸激酶NTRK3（TRKC）（Lamballe等，1991年）的主要配体。NTRK3（TRKC）不被神经生长因子家族的其他成员（如NGF、BDNF和NTF4）激活（Lamballe等，1991年，Ip等，1993年）。NTF3同源二聚体的结合可诱导NTRK3（TRKC）受体的二聚化，从而使得配体：受体复合物的化学计量比为2:2（Philo等，1994年）。在Philo等人的研究中，使用了重组人NTF3与重组的NTRK3（TRKC）细胞外区域，但NTRK3的来源并未明确指出。