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Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21

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Protein Data Bank Japan2024-10-16 更新2026-03-21 收录
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Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21 Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, ... Authors: Chen, S.F, Wang, Y.R, Wu, C.C, Chan, N.L. Deposit date: 2018-04-24 Release date: 2018-08-08 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. Nat Commun, 9, 2018
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2018-04-24
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