Significant mutation frequency differences in PR and RT between sequences with PR L90 and PR M90.

A summarized result of amino acid residue frequencies that are significantly enriched with the absence of L90M mutation is shown in the table. The first column indicates what protein the mutation resides. The second column indicates the mutation and position of occurrence. The third and fourth column note the observed counts of a mutation in either the L90+ or M90+ set. Columns five to seven show the result of the fisher analysis and q-value calculation. The last column describe how the mutation is related to a specific HLA subtype. The first value is the HLA subtype in question, the second value is whether a mutation confers CTL escape, indicated as “ADAPTED” for escape and “NONADAPTED” for susceptibility. The last value indicate whether the mutation is directly involved in CTL escape or exist as a compensatory mutation. Values of deminished HLA subtype associated residues are included for reference purposes elsewhere in the article.