Efficient Detection of 1H, 15N Correlations in Hydrogen Bonded Low Molecular Catalyst-Substrate Intermediates without Selective 15N Labelling

To date SOFAST approaches have generally been reserved to biomolecules. We present the applicability of SOFAST-HMQC techniques to small molecules in the slow-tumbling regime offering a time-efficient characterization of catalyst substrate hydrogen bonds with nitrogen at natural abundance. This extends NMR access to a broader range of catalyst substrate combinations.