Validation of amniotic fluid cathelicidin levels on independent prospective replication cohort.

Amniotic fluid cathelicidin levels in PPROM women with MIAC and HCA were compared with those in whom at least one condition was ruled out. The latter group involved women with neither MIAC nor HCA, without MIAC but with HCA, or with MIAC but without HCA. In line with the validation experiment, amniotic fluid cathelicidin concentrations were significantly higher in women with confirmed MIAC and HCA than in the other women. Cathelicidin levels were measured using a commercial ELISA kit. Values were evaluated using nonparametric Mann-Whitney U test. Graph represents individual values, horizontal bars indicate median values. Abbreviations are explained in the Fig. 2.