Vitamin D status and COVID-19 clinical outcomes in hospitalized patients

Context: Populations severely affected by COVID-19 are also at risk for vitamin D deficiency. Common risk factors include older age, chronic illness, obesity, and non-Caucasian race. Vitamin D deficiency has been associated with risk for respiratory infections and failure, susceptibility and response to therapy for enveloped virus infection, and immune-mediated inflammatory reaction.

Objective: To test the hypothesis that 25-hydroxyvitamin D[25(OH)D] deficiency is a risk factor for severity of COVID-19 respiratory and inflammatory complications.

Design: We examined the relationship between retrospectively obtained prehospitalization 25(OH)D levels and COVID-19 clinical outcomes in 700 COVID-19 positive hospitalized patients.

Primary Outcomes: Discharge status, mortality, length of stay, intubation status, renal replacement

Secondary Outcomes: Inflammatory markers

Results: 25(OH)D levels were available in 93 patients [25(OH)D:25(IQR:17–33)ng/mL]. Compared to those without ...