Table_1_Relationship between the mean of 24-h venous blood glucose and in-hospital mortality among patients with subarachnoid hemorrhage: A matched cohort study.DOCX

ObjectiveThe aim of this study was to explore the correlation between the mean of 24-h venous blood glucose (BG) and in-hospital mortality and all-cause mortality (ACM) in patients with subarachnoid hemorrhage (SAH).MethodsDetailed clinical information was acquired from the Medical Information Mart for Intensive IV (MIMIC-IV) database. The best cutoff value of mean BG was calculated using the X-tile program. Univariate and multivariate logistic regressive analyses were utilized to analyze the prognosis significance of mean BG, and survival curves were drawn using the Kaplan-Meier (K-M) approach. To improve the reliability of results and balance the impact of underlying confounders, the 1:1 propensity score matching (PSM) approach was utilized.ResultsAn overall of 1,230 subjects were selected herein. The optimal cutoff value of the mean BG for in-hospital mortality was 152.25. In addition, 367 pairs of score-matched subjects were acquired after PSM analysis, and nearly all variables' differences were balanced. K-M analysis showed that patients with mean BG ≥ 152.25 mg/dl had significantly higher in-hospital, 3-month, and 6-month mortalities compared with patients with mean BG < 152.25 mg/dl (p < 0.001). The multivariable logistic regressive analyses revealed that patients with mean BG ≥ 152.25 mg/dl had significantly increased in-hospital mortality compared with patients with mean BG < 152.25 mg/dl after the adjustment for possible confounders (OR = 1.994, 95% CI: 1.321–3.012, p = 0.001). Similar outcomes were discovered in the PSM cohort.ConclusionOur data suggested that mean BG was related to ACM of patients with SAH. More studies are needed to further analyze the role of the mean of 24-h venous BG in patients with SAH.

本研究旨在探讨蛛网膜下腔出血（SAH）患者24小时静脉血糖（BG）均值与住院死亡率及全因死亡率（ACM）之间的相关性。研究方法：详细临床信息来源于重症监护医疗信息市场（MIMIC-IV）数据库。使用X-tile程序计算了平均BG的最佳截断值。采用单因素和多因素逻辑回归分析评估平均BG的预后意义，并利用Kaplan-Meier（K-M）方法绘制生存曲线。为提高结果的可信度和平衡潜在混杂因素的影响，采用了1:1倾向得分匹配（PSM）方法。研究结果：共选取了1,230名受试者。住院死亡率的平均BG最佳截断值为152.25。此外，PSM分析后获得了367对得分匹配的受试者，几乎所有变量的差异均得到平衡。K-M分析显示，平均BG≥152.25 mg/dl的患者与平均BG<152.25 mg/dl的患者相比，在住院、3个月和6个月的死亡率显著升高（p<0.001）。多因素逻辑回归分析显示，在调整可能混杂因素后，平均BG≥152.25 mg/dl的患者与平均BG<152.25 mg/dl的患者相比，住院死亡率显著增加（OR=1.994，95%CI：1.321–3.012，p=0.001）。在PSM队列中也发现了类似的结果。研究结论：我们的数据表明，平均BG与SAH患者的ACM相关。需要进一步的研究来分析24小时静脉BG均值在SAH患者中的作用。