RNA splicing and aggregate gene expression differences between lung squamous cell carcinoma from patients of West African and European ancestry. RNA splicing and aggregate gene expression differences between lung squamous cell carcinoma from patients of West African and European ancestry

Study of genes that are differentially spliced and differentially expressed between African Americans and whites with lung squamous cell cancer. Despite racial disparities in lung cancer, the molecular landscape of lung cancer in patients of African ancestry remains underexplored. Population-related differences in alternative RNA splicing have not been explored. We identified differentially spliced genes and differentially expressed genes between lung squamous cell carcinoma from patients of West African and European ancestry. Overall design: RNA extracted from 20 African American and 20 white resected lung tissue was run on Clariom D exon array. Analysis to determine differences between population groups was performed using Transcriptome Analysis Console Software 4.0 (Affymetrix).