Conjugation of carboxylic acids

Xenobiotics and endogenous compounds containing carboxylate groups can be activated with coenzyme A to produce acyl-CoA thioesters and then conjugated with the amino groups of glycine or glutamine to form amide-linked conjugates. Clinically important substrates include benzoic acid, phenylacetic acid, and salicylic acid.

异生物和含有羧基的内源性化合物可通过辅酶A的激活作用生成酰基辅酶A硫酯，随后与甘氨酸或谷氨酰胺的氨基发生结合，形成酰胺键连接的共轭物。在临床医学中具有重要意义的底物包括苯甲酸、苯乙酸和水杨酸。