Supporting data from: Catalytic photooxygenation demonstrates therapeutic efficacy in transthyretin amyloidosis

The escalating global trend of aging populations has brought attention to the rising prevalence of late-onset amyloid disorders. Among them, amyloid transthyretin (ATTR) amyloidosis presents a growing area of unmet medical needs. While current treatment modalities have demonstrated efficacy in preventing or delaying amyloid generation, methodology to selectively modify and neutralize existing amyloid burdens remains inadequately addressed, leaving the fundamental irreversibility and hence the fatality of these conditions a long-standing medical challenge. Here, we report the first demonstration of therapeutic efficacy in ATTR amyloidosis via dynamic control of ATTR aggregation and toxicity, enabled by small-molecule organophotocatalysis. Selective incorporation of hydrophilic oxygen atoms into the hydrophobic amyloid core reshapes the aggregation landscape, neutralizing proteotoxicity and mitigating cellular damage. Additionally, this targeted covalent modification significantly reduces..., , , # Supporting data from: Catalytic photooxygenation demonstrates therapeutic efficacy in transthyretin amyloidosis

[https://doi.org/10.5061/dryad.1vhhmgr31](https://doi.org/10.5061/dryad.1vhhmgr31)

General Notes on File Format: The Excel files contain structured formatting elements (e.g., merged cells, section headers, minimal highlighting, and grouped layouts) that were intentionally retained to preserve the logical organization of the biological experiments. Many datasets compile multiple related experimental conditions, replicates, and image-derived measurements within a single sheet. The formatting is used solely to clarify experimental grouping (e.g., treatment conditions, time points, replicates, and figure correspondence) and to maintain traceability between raw images and quantified values.

No calculations depend on embedded formulas or formatting features. All numerical values used for statistical analysis are provided as static entries and can be readily extracted for indepe..., ,