Crystal structure of GMPPNP-bound wild type KRAS in complex with MRTX1133
收藏Protein Data Bank Japan2026-02-25 更新2026-04-19 收录
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Crystal structure of GMPPNP-bound wild type KRAS in complex with MRTX1133 Descriptor: 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, CHLORIDE ION, GLYCEROL, ... Authors: Bonsor, D.A, Simanshu, D.K. Deposit date: 2025-04-03 Release date: 2026-01-21 Last modified: 2026-02-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors. Nat Commun, 17, 2026
创建时间：
2025-04-03
