Genomic surveillance of Staphylococcus aureus isolates from bloodstream infections in Japan

Comprehensive molecular epidemiology and clinical risk assessment of clonal spread of bloodstream infections-derived MRSA through integrated analysis are still insufficient in Japan. In this study, we reconstructed the phylogenetic relationships based on the whole-genome data of collection strains from almost all over Japan, the late 1990s and late 2010s periods, analyzed the profiles of antimicrobial resistance genotypes, virulence genotypes, and resistance levels to various antibiotics. This study highlights the need for continued national genomic surveillance of high-risk clones to control the healthcare for MRSA bloodstream infections.