Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke. (Source data)

Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke, dataset. <br> Fig. 1 : <em>Dkk1</em> mRNA is detected at the lesion site but not in the intact tissue, and its conditional induction has limited effects in absence of injury. <br> Fig. 2 : Early DKK1 induction accelerates sensorimotor impairments and exacerbates injury. <br> Fig. 3 : Brain perfusion and revascularization are impaired following early DKK1 induction. <br> Fig. 4 : Neuroinflammation and glial scar organization are deregulated after early DKK1 induction. <br> Fig. 5 : Delayed induction of DKK1 hinders neurological recovery, promotes anxiety-like behavior and attenuates synaptic plasticity. <br> Fig. 7 : DKK1 <em>de novo</em> expression at the lesion site after stroke originates from infiltrating BMDCs. <br> Fig. 8 : Pharmacological deactivation of DKK1 promotes structural and neurological recovery. <br> Extended data fig. 1 : Early induction of DKK1 aggravates structural damage after stroke. <br> Extended data fig. 2 : DKK1 induction prior to stroke impairs neuronal differentiation and neuronal activity. <br> Extended data fig. 3 : Delayed DKK1 post-stroke induction does not affect locomotion in the open field test. <br> Extended data fig. 4 : Ischemic stroke modulates the transcriptomic profiles of the brain tissue. <br> Extended data fig. 5 : Validation of chimerism validation in chDKK1 mice. <br> Extended data fig. 6 : DKK1 subacute neutralization reduces brain damage after stroke.

本数据集主题为：髓系Dickkopf-1（Dkk1）驱动缺血性脑卒中后的神经血管与神经免疫改变。<br>图1：在脑卒中损伤部位可检测到Dkk1 mRNA，而在完整脑组织中无该mRNA表达；且在无损伤的生理状态下，其条件性诱导的生物学效应十分有限。<br>图2：早期DKK1诱导表达会加重缺血性脑卒中后的感觉运动功能障碍，并加剧脑组织损伤。<br>图3：早期DKK1诱导表达会损害脑灌注与血管重建过程。<br>图4：早期DKK1诱导表达会导致神经炎症与胶质瘢痕重塑异常。<br>图5：延迟性DKK1诱导表达会阻碍神经功能恢复、诱发焦虑样行为并削弱突触可塑性。<br>图7：脑卒中后损伤部位的DKK1从头表达来源于浸润的骨髓源性细胞（BMDCs）。<br>图8：DKK1的药物靶向灭活可促进脑组织结构与神经功能的恢复。<br>扩展数据图1：早期DKK1诱导表达会加重缺血性脑卒中后的结构性脑损伤。<br>扩展数据图2：脑卒中前DKK1诱导表达会损害神经元分化与神经元活性。<br>扩展数据图3：脑卒中后延迟性DKK1诱导表达对旷场实验中的自主运动无显著影响。<br>扩展数据图4：缺血性脑卒中会调控脑组织的转录组表达谱。<br>扩展数据图5：嵌合DKK1小鼠的嵌合状态验证。<br>扩展数据图6：DKK1的亚急性期中和治疗可减轻缺血性脑卒中后的脑组织损伤。