RAW DATA

This study found that after spinal cord injury, macrophages phagocytize myelin debris to form foamy macrophages, while microglia do not form foamy cells, which may be because microglia can effectively clear myelin debris in a relatively short time, whereas macrophages cannot. In addition, we found that ACAT1 did not mediate the formation of foamy macrophages after spinal cord injury, which was different from atherosclerosis. This study demonstrates that microglia have a stronger ability to clear myelin debris than macrophages and may contribute to the development of novel therapeutic strategies to remove myelin debris more effectively, reduce inflammatory responses, promote remyelination, and accelerate functional recovery after spinal cord injury.

本研究发现，脊髓损伤后，巨噬细胞吞噬髓鞘碎片形成泡沫状巨噬细胞，而小胶质细胞则不形成泡沫细胞，这可能是因为小胶质细胞能够在相对较短的时间内有效清除髓鞘碎片，而巨噬细胞则不能。此外，我们发现ACAT1在脊髓损伤后并未介导泡沫状巨噬细胞的形成，这与动脉粥样硬化不同。本研究证实，小胶质细胞相较于巨噬细胞拥有更强的清除髓鞘碎片的能力，可能有助于开发新型治疗策略，以更有效地清除髓鞘碎片、减轻炎症反应、促进髓鞘再生，并加速脊髓损伤后的功能恢复。