scRNA-Seq of Cdkn2a mutant murine Epithelioid Hemangioendothelioma tumors

Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a TAZ-CAMTA1 fusion in greater than 90% of cases and loss of CDKN2A in human EHE tumors is associated with late stage disease. Murine EHE tumors were created by conditionally expressing TAZ-CAMTA1 and conditionally knocking out Cdkn2a within vascular endothelium. Resultant tumors were used for single cell RNA sequencing and compared against age matched wild type mice tissue. Overall design: scRNA Sequencing of Cdkn2a mutant Epithelioid Hemangioendothelioma Tumors in Mouse