West Point Cohort: Processed Multi-Omics Data (Blood and Saliva)

Processed, analysis-ready multi-omics data from a cohort of healthy 18 to 24-year-old U.S. Military Academy cadets. Blood and saliva specimens were collected from the same subjects. This record is organised by specimen type rather than by publication, because the data support more than one study of this cohort. Blood-derived data (individual files at the top level of this record): DNA methylation beta values, 351 samples, filtered probes (Illumina Infinium MethylationEPIC BeadChip). Gene expression count matrices from 3' mRNA sequencing, in raw and normalized form, with both Gene Name and Ensembl ID identifiers. Saliva-derived data (single archive, West_Point_Cohort_Molecular_Data_Saliva.zip): 14 files covering untargeted metabolomics, untargeted proteomics, and RNA transcriptomics (mRNA, lncRNA, sncRNA, miRNA and tRNA). Within the archive, files prefixed mDat_ hold the measures with one row per sample (a sample is identified by the first three columns), and files prefixed hDat_ hold the feature information with one row per molecular feature. The two are joined on the measurement_id column. A ReadMe inside the archive gives the full file list, dimensions and column conventions. Data type. Every file in this record is a processed matrix; no raw instrument data are included here. Related data for this cohort. Raw DNA methylation array data (702 IDAT files) together with the processed beta value matrix are in ArrayExpress under accession E-MTAB-16584. Additional blood-derived assay types and the PhenoMol analytical pipeline code are in figshare under doi:10.6084/m9.figshare.30724577. West Point phenotypic data may be made available by request after review by the United States Military Academy Institutional Research Committee ([e-mail]). See README.txt in this record for the complete file-by-file description.