Change in T2-LV and T1-LV over time in patients with increasing and decreasing VW-MTR (mm3).

aFailed analysis or missing MRI at Week 24.bFor the difference from zero within groups from the Wilcoxon signed–rank test.cAdjusted for multiple comparisons with the Holm-Bonferroni correction.dFor the difference between the first 12 weeks and the second 12 weeks from the Wilcoxon signed–rank test.LV, lesion volume; Max, maximum; Min, minimum; MRI, magnetic resonance imaging; NS, non-significant; SD, standard deviation; VW-MTR, voxel-wise magnetic transfer ratio.