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IC50 values of macitentan, bosentan and ambrisentan obtained in calcium flux assays using transgenic cells expressing the indicated point-mutated ETA receptor variants.

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Figshare2015-12-02 更新2026-04-29 收录
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The right half of the table represents the loss in potency (fold IC50 shift) for each compound on each receptor variants compared to the wildtype receptor. IC50 values represent geometric means of n = 4–5 independent determinations.IC50 values of macitentan, bosentan and ambrisentan obtained in calcium flux assays using transgenic cells expressing the indicated point-mutated ETA receptor variants.
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2015-12-02
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