NCBI Genetic Sequence Database

GenBank ® is the NIH genetic sequence database of annotated collections of all publicly available DNA sequences. GenBank is part of an International Nucleotide Sequence Database Collaboration, which comprises the DNA DataBank of Japan (DDBJ), the European Nucleotide Archive (ENA), and GenBank at NCBI. The GenBank database is designed to provide and encourage access within the scientific community to the most up-to-date and comprehensive DNA sequence information, and release available versioned collections every two months from the ftp site. As part of the International Nucleotide Sequence Database Collaboration (INSDC), a long-standing foundational initiative (operating between DDBJ, EMBL-EBI and NCBI), the INSDC covers the spectrum of data raw reads, through alignments and assemblies to functional annotation, enriched with contextual information relating to samples and experimental configurations. GenBank data submission types include: mRNA sequences, Prokaryotic genes, Eukaryotic genes, rRNA and/or ITS, viral sequences, transposon or insertion sequences, microsatellite sequences, pseudogenes, cloning vectors, phylogenetic or population sets, and non-coding RNAs.

GenBank® 是美国国立卫生研究院（National Institutes of Health, NIH）旗下的基因序列数据库，收录所有公开可用DNA序列的注释合集。GenBank 隶属于国际核苷酸序列数据库协作组（International Nucleotide Sequence Database Collaboration, INSDC），该协作组由日本DNA数据库（DNA DataBank of Japan, DDBJ）、欧洲核苷酸档案馆（European Nucleotide Archive, ENA）以及美国国家生物技术信息中心（National Center for Biotechnology Information, NCBI）的GenBank共同组成。该数据库旨在为科研共同体提供并推广获取最新、最全面的DNA序列信息的途径，每两个月会通过FTP站点发布带版本号的数据集合集。作为国际核苷酸序列数据库协作组（INSDC）的组成部分——这是一项由DDBJ、欧洲分子生物学实验室-欧洲生物信息研究所（European Molecular Biology Laboratory - European Bioinformatics Institute, EMBL-EBI）与NCBI共同运营的长期基础性合作项目——INSDC 覆盖了从原始测序读段、序列比对与基因组组装到功能注释的全谱系数据，并补充了与样本及实验配置相关的上下文信息。GenBank 的数据提交类型涵盖：信使RNA（messenger RNA, mRNA）序列、原核生物基因、真核生物基因、核糖体RNA（ribosomal RNA, rRNA）和/或内转录间隔区（internal transcribed spacer, ITS）、病毒序列、转座子或插入序列、微卫星序列、假基因、克隆载体、系统发育或群体数据集，以及非编码RNA（non-coding RNA, ncRNA）。

搜集汇总

背景与挑战

背景概述

GenBank是美国国立卫生研究院（NIH）维护的遗传序列数据库，收录所有公开可用的DNA序列注释集合，并作为国际核苷酸序列数据库合作的一部分。该数据库旨在为科学界提供最新、全面的DNA序列信息，涵盖mRNA、原核与真核基因、病毒序列等多种数据类型，并每两个月发布更新版本。