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Genome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma

ChEBI2010-07-30 更新2026-07-21 收录

癌症表观遗传学

药物靶点发现

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-19243 数据链接链接失效反馈

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Genome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma

应用场景：

创建时间：

2010-07-30

癌症表观遗传学

药物耐药性

Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic

DataONE2020-06-24 更新60

IMPRINTS-CETSA Docetaxel and Paclitaxel in MCF-7 cells, 8h incubation

药物靶点发现

化疗疗效评估

IMPRINTS-CETSA data acquisition of MCF-7 cells treated with Vehicle (DMSO), Docetaxel or Paclitaxel using TMT 10 plex.

NIAID Data Ecosystem10

Genes we prioritised as drug targets that had MR and colocalization evidence with other indications.

药物靶点发现

基因-疾病关联

Gene expression-disease relationship identified in the main MR (instrument-gene-indication): Alzheimer’s disease (AD), Schizophrenia (Sz), anorexia (AN), suggested direction of drug action according t

Figshare2021-01-08 更新00

Catalytic Domain of Human Calpain 8

蛋白酶结构解析

药物靶点发现

Catalytic Domain of Human Calpain 8 Descriptor: CALCIUM ION, Calpain-8, Leupeptin Inhibitor Authors: Davis, T.L, Paramanathan, R, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith,

Protein Data Bank Japan2024-10-30 更新30

Crystal structure of the PIN1 and fragment 35 complex.

蛋白质晶体学

药物靶点发现

Crystal structure of the PIN1 and fragment 35 complex. Descriptor: (1-methylindazol-3-yl)methanol, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Protein Data Bank Japan2025-10-15 更新00

Genome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma

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