Molecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 2)

In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabetic on normal diet). In this model one can search for parameters that distinguish females fed normal diet compared to high fat diet (i.e. components that vary with the development of diabetes) and evaluate if such changes can be related to components that characterize male diabetic animals..本研究分析了雌雄Zucker糖尿病肥胖（Zucker diabetic fatty, ZDF）大鼠肝脏中的基因表达与代谢物水平。我们推测，ZDF大鼠糖尿病发生的性别差异特征（正常饮食条件下仅雄性个体罹患糖尿病）为探究性别与糖尿病的关联提供了研究契机。在此动物模型中，可筛选能够区分正常饮食与高脂饮食雌性大鼠的相关参数（即随糖尿病发病进程发生变化的组分），并评估此类变化是否与雄性糖尿病模型动物的特征性组分存在关联。