Crystal structure of TYK2 kinase domain in complex with compound 16
收藏Protein Data Bank Japan2024-10-23 更新2026-04-19 收录
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Crystal structure of TYK2 kinase domain in complex with compound 16 Descriptor: 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5H-pyrrolo[3,4-d]pyrimidin-5-one, Non-receptor tyrosine-protein kinase TYK2 Authors: Toms, A.V, Leit, S, Greenwood, J.R, Mondal, S, Carriero, S, Dahlgren, M, Harriman, G.C, Kennedy-Smith, J.J, Kapeller, R, Lawson, J.P, Romero, D.L, Shelley, M, Wester, R.T, Westlin, W, Mc Elwee, J.J, Miao, W, Edmondson, S.D, Massee, C.E. Deposit date: 2022-05-07 Release date: 2022-08-24 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg.Med.Chem.Lett., 73, 2022
创建时间：
2022-05-07
