Access to 4,6-Diarylpicolinates via a Domino Reaction of Cyclic Sulfamidate Imines with Morita–Baylis–Hillman Acetates of Nitroolefins/Nitrodienes

An
interesting domino reaction of 5-membered cyclic sulfamidate
imines with a variety of Morita–Baylis–Hillman acetates
of nitroolefins/nitrodienes in the presence of DABCO as an organic
base at 55 °C is reported for the first time. This new synthetic
strategy provides a series of pharmacologically interesting 4,6-diarylpicolinates
in high to excellent yields and allows several compatible functionalities
on aryl rings. Moreover, the biologically interesting imidazo­[1,2-a]­pyridine (alpidem derivative) has been prepared in high
chemical yield through a unique procedure.