Atopic Dermatitis GWAS meta-analysis summary statistics

Multi-ancestry GWAS meta-analysis on 12 cohorts comprising a total of 56,146 AD cases and 602,280 controls of European (EUR), Asian (ASN), African (AFR), American (AMR) and admixed ancestries (AD_GWAS_12meta_FE_hg38.txt.gz). Ancestry-stratified GWAS statistics were obtained by performing an analogous meta-analysis strategy considering cohorts stratified by continental populations: EUR, ASN, AFR (AD_GWAS_EUR_meta_FE_hg38.txt.gz, AD_GWAS_ASN_meta_FE_hg38.txt.gz, AD_GWAS_AFR_meta_FE_hg38.txt.gz).GWAS meta-analysis statistics were obtained by fixed-effect (FE) inverse variance weighted meta-analysis of the summary statistics (beta values) from each cohort using GWAMA. Genomic locations provided for human genome build 38 and hg19 (see column headers).<b>GWAS meta-analysis design:</b><b>Meta-analysis</b><b># cohorts</b><b>Ancestry</b><b># Cases</b><b># Controls</b><b># GWS loci</b><b>Lambda GC (all variants)</b>Multi-ancestry12EUR, EAS, CSA, SAS, AFR, AMR56146602280941.054968EUR-only4EUR42963408472761.089119ASN-only4ASN5014171135121.054628AFR-only2AFR70631587901.016833<b>Each file contains the following column headers:</b><br><b>CHR:</b> hg38 marker chromosome<br><b>POS:</b> hg38 marker position (bp)<br><b>REF:</b> reference allele<br><b>ALT:</b> effect allele<br><b>MARKER:</b> marker in format chr:pos:ref:alt (ex. 1:10177:A:AC)<br><b>rsID:</b> dbSNP rsID<br><b>PVAL:</b> meta-analysis p-value<br><b>BETA:</b> overall beta value for meta-analysis<br><b>SE:</b> beta standard error<br><b>Z:</b> Z-score<br><b>ALT_AF:</b> alternate/effect allele frequency<br><b>n_studies:</b> number of studies with marker present<br><b>n_samples:</b> number of samples with marker present<br><b>effects:</b> summary of effect directions ('+' - positive effect of reference allele, '-' - negative effect of reference allele, '0' - no effect (or non-significant) effect of reference allele, '?' - missing data)<br><b>hg19_CHR:</b> hg19 marker chromosome<br><b>hg19_POS:</b> hg19 marker position