Caenorhabditis elegans Hawaiian Strain CB4856 Genome Assembly. Caenorhabditis elegans strain:CB4856

Among the many wild isolates of C. elegans, one of the most genetically divergent and most heavily studied is CB4856, which was isolated in 1972 by Linda Holden from a pineapple field on the Hawaiian island of Maui (under the name HA8) (HODGKIN AND DONIACH 1997). It shows multiple phenotypic differences with N2, including production of a copulatory plug, aggregation (social) behavior, a lack of temperature-size dependence, growth rate, fecundity and RNAi insensitivity by feeding and drug resistance (DE BONO AND BARGMANN 1998; KAMMENGA et al. 2007; GHOSH et al. 2012; POLLARD AND ROCKMAN 2013; ANDERSEN et al. 2014) as well as gene expression differences (CAPRA et al. 2008; VINUELA et al. 2012; VOLKERS et al. 2013). We have undertaken the construction of a C. elegans Hawaiian strain CB4856 reference genome sequence.