Additional file 7 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Here we introduce a strategy to edit endogenous amyloid precursor protein (APP) at the extreme C-terminus and selectively attenuate the amyloidogenic pathway – a key pathologic cascade in Alzheimer’s
Transcriptome analysis of human iPSC-derived hippocampal neurons overexpresing NEUROD1 We employed Affymetrix GeneChip microarray (Human Clariom D) to examine early transcriptomic changes in APP varia
Overall risk for Major Depressive Disorder (MDD) is determined by complex interactions between genetic and environmental factors that influence epigenetic regulation of neuroplasticity and stress path
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by miRNAs, but it is unknown whether microglial miRNAs have sex-specific influen