Transcriptomic characterization of the diabetic retinal response to chronic insulin treatment

The aim of this study was to identify alterations associated with diabetes-induced functional dysregulation of the retina and the effects of chronic insulin therapy. Transcriptional profiling through microarray analysis was analyzed to find mRNA targets of interest in diabetic samples, as well as in the insulin treated group. Verification of targets shown to be unrecovered in the insulin group was validated.本研究旨在探明与糖尿病诱导的视网膜功能失调相关的分子改变，以及慢性胰岛素治疗的干预效果。本研究通过微阵列分析（microarray analysis）开展转录组谱分析（transcriptional profiling），以筛选糖尿病样本与胰岛素处理组样本中具备研究价值的mRNA靶标。本研究对胰岛素处理组中未恢复至正常水平的靶标完成了验证实验。