Cleavage of ERBB4m80 by gamma-scretase complex
收藏reactome.org2025-01-09 收录
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After ERBB4 is cleaved by ADAM17, gamma-secretase complex performs additional cleavage in the transmembrane region of the m80 ERBB4 fragment, releasing the soluble ERBB4 intracellular domain of 80 kDa, known as s80 or E4ICD (Ni et al. 2001).
继ADAM17对ERBB4进行裂解之后，γ-分泌酶复合体在m80 ERBB4片段的跨膜区域进行进一步的裂解，从而释放出80 kDa的可溶性ERBB4细胞内结构域，被称为s80或E4ICD（Ni等，2001年）。
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