Gene expression in duodenal biopsy samples from CVID enteropathy patients and healthy controls

A subgroup of CVID patients presents with gastrointestinal complications (enteropathy), which manifests in the duodenum as celiac like-diese ase. CVID enteropathy patients can present with severe histopathology in form of villous atrophy (CVID VA) or without VA (CVID noVA). RNAseq data from CVID VA and CVID noVA derived duodenal tissues were compared to each other and to healthy controls. Overall design: Duodenal biopsies derived from CVID patients and healthy controls during endoscopic procedures were dispersed using a homogenizer (T10, IKA) and total RNA was extracted using Rneasy Plus Mini Kit (Qiagen) according to manufacturer's instructions.