BIOGRID CURATED DATA FOR MGE1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for MGE1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress

MGE1（酿酒酵母S288c）的蛋白质-蛋白质、遗传和化学相互作用数据集，由BioGRID（https://thebiogrid.org）整理；定义：线粒体基质共伴侣蛋白；蛋白质转运和折叠中的Ssc1p核苷酸释放因子；亦充当Fe-S簇蛋白折叠中的Ssq1p共伴侣蛋白；作为氧化应激传感器以调节线粒体中Ssc1p的功能；在氧化应激存在的情况下，二聚体Mge1p变为单体，无法调节Ssc1p功能；与大肠杆菌GrpE和人类Mge1（GRPEL1）的同源物，后者亦对氧化应激做出响应。