Summary of non-synonymous mutations for EPHB6 (NM_004445 and NP_004436) found in tumors.

Note: The table contains data from the databases of http://www.sanger.ac.uk/genetics/CGP/cosmic/, http://strubiol.icr.ac.uk/extra/mokca, and the references were listed in the column of “Pubmed Id”. The NSCLC mutations identified in this study were marked as “not reported”. Two sequence homology-based tools were used to predict the potential impact of the identified non-synonymous substitutions on protein function: Sort Intolerant from Tolerant (SIFT; http://sift.bii.a-star.edu.sg/) and Polymorphism Phenotype (PolyPhen-2; http://genetics.bwh.harvard.edu/pph2/). If the SIFT prediction tolerance index score was less than 0.05, the variation was considered possibly damaging. Predictions made by PolyPhen-2 were assigned as “probably damaging,” “possibly damaging” or “benign.” Deletion mutations cannot be tested by either SIFT or PolyPhen-2.